I have been taking Cymbalta for 3 years. Prior to taking this med, I could have a few beers or a glass of wine and be finished for the night. Within the last few years, I had progressed to the point of drinking when I wake up in the morning. Drinking in quantity as you are ultimately makes the depression worse. Anxiety is a natural response to cutting back on the alcohol, but will gt better with continued reduction of alcohol consumption. I understand that using alcohol while taking Cymbalta can cause one to feel more drunk and black out, but is is possible that it can also cause headaches the next day? Further, long-term heavy alcohol use while taking an antidepressant such as Cymbalta can make your antidepressant less effective. As a result, your treatment may take longer or be compromised. I have been taking Cymbalta for about 8 months now. In the last few months it seems that I am drinking more alcohol and when I start drinking I don't stop. Combining Cymbalta and alcohol can cause serious side effects to occur. You should not use alcohol if you are taking this medication. If you must drink alcohol, it is recommended that you do so in moderation and only after you have been taking Cymbalta for a period of time. In addition to knowing about the potential interaction of alcohol and side effects, some people have found that using Cymbalta has actually changed their drinking habits, so there is also information on the concepts of craving, blackout and side effects related to alcohol and Cymbalta. Be careful when drinking alcohol while you are taking this medicine. Drinking large amounts of alcohol during treatment with CYMBALTA can cause severe liver injury. Cymbalta can increase the effects of alcohol, such as increasing the symptoms of depression or affecting motor skills. Therefore, some healthcare providers recommend that people should not combine Cymbalta and alcohol. I've been on Cymbalta for over a year and it has really effected my use of alcohol. I used to be a moderate drinker before Cymbalta but now if I have more then 2 drinks I get incredibly woozy and start slurring.